En Russe
Identifieur interne : 001792 ( Main/Exploration ); précédent : 001791; suivant : 001793En Russe
Auteurs : A. R. Rekstin ; A. N. Naikhin ; I. B. Barantseva ; L. G. RudenkoSource :
- Voprosy virusologii [ 0507-4088 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The quantitative estimation of the production of the virus specific IgA-, Igm-,IgG1, IgG2a, IgG2b and IgG3 -antibody secreting B-cells (ASC) and extent of the immune response of the cytotoxic T-lymphocytes was carried out in mice after primary and secondary immunization with the parental cold adapted (ca) virulent epidemic wild-type (wt) master strain viruses and their reassortant variants (RV) with the incorporated in their genom different genes from ca master strain. The chick embryo derived ca master strain virus A/Len/134/47/57 (H2N2)reduced or eliminated the viral potency to induce the primary B-cellular response. Reassortant Incorporation of wt derived HA and NA genes into the ca virus genome restored the virus immunogenic activity concerning the ASC production, but at the lower level than parental virulent virus. Reassortance of the viruses according to generally accepted genom formula 6/2 was associated with decrement of the functional activity of the cytotoxic T-lymphocytes memory and of the primary immune response especially. The data obtain demonstrate the necessity for the contol of the immunogenicity of the reassortant viruses at the cloning stage.
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Main, to step Curation: 001792
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="RUS" level="a">En Russe</title><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Naikhin, A N" sort="Naikhin, A N" uniqKey="Naikhin A" first="A. N." last="Naikhin">A. N. Naikhin</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Barantseva, I B" sort="Barantseva, I B" uniqKey="Barantseva I" first="I. B." last="Barantseva">I. B. Barantseva</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0065419</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 03-0065419 INIST</idno><idno type="RBID">Pascal:03-0065419</idno><idno type="wicri:Area/PascalFrancis/Corpus">000065</idno><idno type="wicri:Area/PascalFrancis/Curation">000009</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000065</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000065</idno><idno type="wicri:Area/Main/Merge">001831</idno><idno type="wicri:Area/Main/Curation">001792</idno><idno type="wicri:Area/Main/Exploration">001792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="RUS" level="a">En Russe</title><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Naikhin, A N" sort="Naikhin, A N" uniqKey="Naikhin A" first="A. N." last="Naikhin">A. N. Naikhin</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Barantseva, I B" sort="Barantseva, I B" uniqKey="Barantseva I" first="I. B." last="Barantseva">I. B. Barantseva</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name><affiliation><wicri:noCountry>no AF</wicri:noCountry></affiliation></author></analytic><series><title level="j" type="main">Voprosy virusologii</title><title level="j" type="abbreviated">Vopr. virusol.</title><idno type="ISSN">0507-4088</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Voprosy virusologii</title><title level="j" type="abbreviated">Vopr. virusol.</title><idno type="ISSN">0507-4088</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>B-Lymphocyte</term><term>Cytotoxic T lymphocyte</term><term>Cytotoxicity</term><term>Gene</term><term>IgA</term><term>IgG1</term><term>IgG3</term><term>IgM</term><term>Immune response</term><term>Immunization</term><term>Influenza</term><term>Mouse</term><term>T-Lymphocyte</term><term>Virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus</term><term>Souris</term><term>Lymphocyte B</term><term>Cytotoxicité</term><term>Lymphocyte T cytotoxique</term><term>Réponse immune</term><term>IgA</term><term>IgM</term><term>IgG1</term><term>IgG3</term><term>Grippe</term><term>Immunisation</term><term>Gène</term><term>Anticorps</term><term>Lymphocyte T</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The quantitative estimation of the production of the virus specific IgA-, Igm-,IgG<sub>1</sub>, IgG<sub>2a</sub>, IgG<sub>2b</sub> and IgG<sub>3</sub> -antibody secreting B-cells (ASC) and extent of the immune response of the cytotoxic T-lymphocytes was carried out in mice after primary and secondary immunization with the parental cold adapted (ca) virulent epidemic wild-type (wt) master strain viruses and their reassortant variants (RV) with the incorporated in their genom different genes from ca master strain. The chick embryo derived ca master strain virus A/Len/134/47/57 (H2N2)reduced or eliminated the viral potency to induce the primary B-cellular response. Reassortant Incorporation of wt derived HA and NA genes into the ca virus genome restored the virus immunogenic activity concerning the ASC production, but at the lower level than parental virulent virus. Reassortance of the viruses according to generally accepted genom formula 6/2 was associated with decrement of the functional activity of the cytotoxic T-lymphocytes memory and of the primary immune response especially. The data obtain demonstrate the necessity for the contol of the immunogenicity of the reassortant viruses at the cloning stage.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Barantseva, I B" sort="Barantseva, I B" uniqKey="Barantseva I" first="I. B." last="Barantseva">I. B. Barantseva</name><name sortKey="Naikhin, A N" sort="Naikhin, A N" uniqKey="Naikhin A" first="A. N." last="Naikhin">A. N. Naikhin</name><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A. R." last="Rekstin">A. R. Rekstin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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